Full cis-Mendelian randomisation (cis-MR) results and genetic instruments for 3,469 druggable genome targets tested across 10 QTL datasets (blood, brain, and cerebrospinal fluid) for association with major depression (MD). These data accompany the manuscript ter Kuile AR et al. (2026) "An integrative Mendelian randomisation and drug mechanism framework for target prioritisation and therapeutic repurposing in major depression", published in Translational Psychiatry (https://doi.org/10.1038/s41398-026-04137-9). MR results: cis_mr_results_all_targets.tsv Primary cis-MR results (IVW or Wald) for 3,469 druggable genome targets tested across 10 discovery QTL datasets and 3 replication pQTL datasets against the PGC Phase 3 major depression (MD) GWAS. Includes both significant and non-significant results. Effect estimates are reported as log-odds ratios (beta) and odds ratios with 95% confidence intervals. Fixed-effects IVW was applied for targets with fewer than 4 instruments; random-effects IVW for 4 or more. Bonferroni significance threshold: p < 3.9 x 10-6 (correcting for 12,794 tests across 10 discovery datasets). Column definitions:symbol = HGNC gene symbolensembl_id = Ensembl gene identifieruniprot_id = UniProt protein identifierdataset = QTL dataset nametissue_type = tissue of originmodality = molecular trait type (pQTL or eQTL)analysis_stage = Discovery or Replicationmr_method = Wald (single instrument) or IVW (multiple instruments)n_instruments = number of genetic instruments after filteringeffect_type = fixed or random effectsbeta = log-odds ratiose = standard errorp_value = p-valuebonferroni_significant = TRUE/FALSEor = odds ratioor_lower_ci = OR 95% CI lower boundor_upper_ci = OR 95% CI upper boundsample_size_exposure = QTL dataset sample sizesample_size_outcome = MD GWAS sample sizen_cases_outcome = MD GWAS case count Genetic instruments, files 2-14: [dataset]_variant_table.tsv.gz Genetic instruments (variant-level data) for the primary cis-MR model in each QTL dataset. One file per dataset. Instruments were selected as cis-acting variants (within 200kb of the target-encoding gene) at p < 1 x 10-6, clumped to LD R-squared < 0.4 using a reference panel of 5,000 UK Biobank participants, with heterogeneity-based pruning applied. Genomic coordinates are on GRCh38. Column definitions:symbol = HGNC gene symbolensembl_id = Ensembl gene identifieruniprot_id = UniProt protein identifierchr_name = chromosomestart_pos = base pair position (GRCh38)effect_allele = effect alleleother_allele = reference alleleeffect_size_exposure = variant-exposure effect estimatestandard_error_exposure = variant-exposure standard errorpvalue_exposure = variant-exposure p-valuef_statistic = single-variant F statistic (z-squared)effect_size_outcome = variant-outcome effect estimate (log-OR)standard_error_outcome = variant-outcome standard errorpvalue_outcome = variant-outcome p-valuedataset_exposure = QTL dataset name