Supplementary Dataset for the manuscript: "Evolutionary divergence and functional insights into the heteromeric cis-prenyltransferase of Paramecium tetraurelia" alignment.fst - FASTA file containing structure-based multiple sequence alignment (Figure 1). structures.rar - RAR archive containing superimposed protein Alphafold3 structural models used for making the multiple sequence alignment. tree.txt - phylogenetic tree (Figure 2) in NEWICK format. Supplementary figures and tables pdf format.