Joint statistical inference of clonal populations from single cell and bulk tumour sequencing data

Salehi, Sohrab; Steif, Adi; Roth, Andrew; Aparicio, Sameul; Bouchard-Côté, Alexandre; Shah, Sohrab;
  • Publisher: Zenodo
  • Identifiers: doi: 10.5281/zenodo.220987
  • Subject: intra-tumour heterogeneity; clonal evolution; joint probabilistic model; distance dependent; Chinese restaurant process; single cell sequencing; next generation sequencing

<p>A statistical framework leveraging data obtained from both single cell and bulk sequencing strategies. The ddClone (Salehi et al.) approach is predicated on the notion that single cell sequencing data will inform and improve clustering of allele fractions derived fro... View more
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