Crispro Identifies Functional Protein Coding Sequences Based On Genome Editing Dense Mutagenesis

Schoonenberg, Vivien A. C.; Cole, Mitchel A.; Yao, Qiuming; Macias-Trevino, Claudio; Sher, Falak; Schupp, Patrick G.; Canver, Matthew C.; Maeda, Takahiro; Pinello, Luca; Bauer, Daniel E.;

<p>CRISPR/Cas9 pooled screening permits parallel evaluation of comprehensive guide RNA libraries to systematically perturb protein coding sequences <em>in situ</em> and correlate with functional readouts. For the analysis and visualization of the resulting datasets we h... View more
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