Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

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Goncalves, Emanuel; Behan, Fiona M; Louzada, Sandra; Arnol, Damien; Stronach, Euan; Yang, Fengtang; Yusa, Kosuke; Stegle, Oliver; Iorio, Francesco; Garnett, Mathew J;
(2019)
  • Publisher: Figshare
  • Related identifiers: doi: 10.5281/zenodo.2530755
  • Subject: Molecular Biology | Python | Crispy | Developmental Biology | Microbiology | Plant Biology | Ploidy | Computational Biology | Hematology | Structural Rearrangements | Genetics | Biochemistry | Copy-number | CRISPR
    • FOR: 69999 Biological Sciences not elsewhere classified

<p>CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRISPR-Cas9 gene-editing has not yet bee... View more
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