The Avicenna Public & Patient Involvement (PPI) task force present their first position paper with focus on assessing the status quo and proposing an action plan for establishing PPI within in silico medicine. While PPI has gained significant momentum in the wider biomedical community, it is currently underserved in the in silico medicine domain. The task force therefore aims to create awareness, support implementation, and enable a culture change within the in silico medicine community to maximise societal impact together with patients and the public. This position paper shall serve as a beacon for establishing the PPI task force within the AA and beyond.