Metabolic maladies, such as obesity and type 2 diabetes, have reached epidemic proportions around the world., imposing a significant burden on public health. Recent evidence suggests that persistent mild inflammation and immune dysregulation are important in the aetiology of these diseases. This research paper aims to investigate the role of inflammation and immune dysregulation in the development and progression of metabolic disorders, with a specific focus on obesity and type 2 diabetes. By analyzing current literature, epidemiological studies, and mechanistic research, we aim to provide insights into the underlying mechanisms, potential therapeutic targets, and future directions in managing these disorders. Keywords: immune dysregulation, metabolic disorders, obesity, type 2 diabetes, therapeutic targets.