The current study demonstrates the analgesic and anti-inflammatory activity of the aqueous extract of Desmodium gangetium whole plant at two different doses i.e., 200mg/kg and 400mg/kg body weight when given orally. This study was conducted in wister albino rats in which paw edema was induced by carrageenin. This is compared with the standard drug Diclofenac which was given at a dose of 10mg/kg. In Swiss albino mice, the analgesic effect was evaluated using Eddy’s hot plate method which was then compared with the standard Aspirin at 25mg/kg dose. The obtained results specify that there has been a notable anti-inflammatory action of Desmodium gangetium when compared to Indomethacin and significant analgesic action when compared to Diclofenac. These results suggest the presence of anti-inflammatory and analgesic activities inDesmodium gangetium. So the extracts of this plant could be used in treating these symptoms. Key Words: Desmodium gangetium, Anti-inflammatory, Analgesic, Diclofenac.