The “international network initiative on safe and sustainable nanotechnology” (INISS-nano) is focussing on the collaboration in different fields pertaining to nanotechnology research in general and nano-safety research in particular. This shall include collaboration in terms of e.g., training, standardisation efforts, test-guidelines development, metrology, commercialisation, ethical aspects, respsonible science and research, sustainability, and joint research, supporting governance, regulatory guidance, and of course being open for further joint working items. This document is a revision of the first version (which has been published in June 2021) and shows descriptions and an action plan for each of the pillars: Harmonization Support industrial understanding Sharing / facilitate sharing of resources / infrastructures International collaboration on ethical and societal aspects of nanotechnology