This dataset contains satellite-derived chlorophyll-a data of Lake Hume (Australia) for the period 21 Mar. 2013 - 01 Feb. 2021. Chlorophyll-a concentrations have been calculated using Mixture Density Networks and Sentinel-2 and Landsat 8 imagery. Mixture Density Networks are a class of neural networks that tackle the inverse problem by modelling the multimodal distribution of target variables using a mixture of Gaussians. For more information, please refer to the following: Pahlevan, N., Smith, B., Alikas, K., Anstee, J., et al. (2022). Simultaneous retrieval of selected optical water quality indicators from Landsat-8, Sentinel-2, and Sentinel-3. Remote Sensing of Environment, 270, 112860 Smith, B., Pahlevan, N., Schalles, J., et al. (2021). A Chlorophyll-a Algorithm for Landsat-8 Based on Mixture Density Networks. Frontiers in Remote Sensing, 1 Pahlevan, N., Smith, B., Schalles, J., et al. (2020). Seamless retrievals of chlorophyll-a from Sentinel-2 (MSI) and Sentinel-3 (OLCI) in inland and coastal waters: A machine-learning approach. Remote Sensing of Environment, 240, 111604