Open Science practices can be challenging for researchers: They may need to overthink their scientific workflow and some previously practiced research methods as well as to learn new practices such as preregistration or replication. Moreover, opening up their research may require additional steps in the scientific process and possibly also additional resources. In February 2021, the University of Mannheim has established an Open Science Office supporting researchers at all career stages and from all disciplines. The Open Science Office of the University of Mannheim offers individual consultations, trainings in various formats as well as Open Science grants and Open Science checks. It is tightly intertwined with the already existing Open Access support and interacts with the research data center, research support unit and other players within and outside the university.