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ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2020
License: CC BY
Data sources: Datacite
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Development and Optimization of an IQF USP5 Activity Assay

Research datakeyboard_double_arrow_right Dataset 05 Nov 2020Publisher:Zenodo
Authors: Mann, Mandeep; Harding, Rachel; Schapira, Matthieu;

doi: 10.5281/zenodo.4247575 , 10.5281/zenodo.4247576

Development and Optimization of an IQF USP5 Activity Assay

Abstract

The Structural Genomics Consortium is a registered charity (no: 1097737) that receives funds from; AbbVie, Bayer AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genentech, Genome Canada through Ontario Genomics Institute [OGI-196], EU/EFPIA/OICR/McGill/KTH, Diamond Innovative Medicines Initiative 2 Joint Undertaking [EUbOPEN grant 875510], Janssen, Merck KGaA (aka EMD in Canada and US), Merck & Co (aka MSD outside Canada and US), Pfizer, Takeda and Wellcome [106169/ZZ14/Z].

Development and optimization of a fluorescence based deubiquitinase (DUB) activity assay for USP5 with internally quenched fluorophore pair (IQF) substrates: di-ubiquitin lysine linked K48 and K63 (Ub2K48, Ub2K63). The inhibitory capability of USP5 zinc-finger ubiquitin binding domain (ZnF-UBD) ligands was investigated.

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Keywords

iqf, zinc finger, usp5, ubiquitin, assay

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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