Depression is a common mental disorder, characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration.the present study has tried to explore depression among grey-collar workers and also tried to explore the effectiveness of vipassana meditation on controlling depressive thoughts among grey-collar workers. It made use of purpose sampling in selecting 100 grey-collar workers equally divided into males and females. The sample responded to the valid and reliable instrument. Beck depression inventory (BDI) construct by Beck, et al (1961) was used to measure depression of the grey-collar workers . The design which was used to conceptualize the study and analyze the data was 2x2 factorial design with two indepandent variables: one being before and after conditions of vipassana therapy and another being gender of the respondents. Results of the present study have revealed that the vipassana meditation has significantly decreased the level of depression among grey-collar workers.