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IN SITU BIO-ACTIVATION AND INACTIVATION MECHANISM IN PSORALEA CORYLIFOLIA EXTRACT AND ASSOCIATED SAFETY FOR PSORIASIS AND VITILIGO

Authors: Aruna V*1, Soundharya R2;

IN SITU BIO-ACTIVATION AND INACTIVATION MECHANISM IN PSORALEA CORYLIFOLIA EXTRACT AND ASSOCIATED SAFETY FOR PSORIASIS AND VITILIGO

Abstract

The present study deals with the in situ bio-activation and inactivation mechanism of Psoralea corylifolia extract and its associated safety. The natural extracts of Psoralea corylifolia showed photosensitivity only instantaneously whereas after 30 minutes no photosensitivity was observed. The possible dermal reaction with various other bio-molecules of Psoralea corylifolia extract may be ‘switching off’ the activity of Trioxsalen and Methoxsalen. The programmed inactivation of photosensitivity of Psoralea corylifolia extract clearly highlights its efficacy and safety over synthetic derivatives of Psoralen- Trioxsalen and Methoxsalen. TLC, Spectrogram, cyanotype paper based photo reaction and volunteer based study were conducted to establish the above scientific fact. Details are presented in the paper.

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Aruna V*1, Soundharya R2, Amruthavalli GV3 & Gayathri Rajagopal4, Aruna V*1, Soundharya R2, Amruthavalli GV3 & Gayathri Rajagopal4

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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