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ABSTRACT Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N -oxide (62% of the total absorbance), N -acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).
Enrofloxacin, Magnetic Resonance Spectroscopy, Quinolones, 10.1128/AEM.66.6.2664-2667.2000, Anti-Infective Agents, Mucor, Mucor ramannianus, Biotransformation, Chromatography, High Pressure Liquid, Fluoroquinolones
Enrofloxacin, Magnetic Resonance Spectroscopy, Quinolones, 10.1128/AEM.66.6.2664-2667.2000, Anti-Infective Agents, Mucor, Mucor ramannianus, Biotransformation, Chromatography, High Pressure Liquid, Fluoroquinolones
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