The aim of the present study is to formulate and evaluate solid lipid nanoparticles of Etoricoxib. Etoricoxib is a selective COX-2 inhibitor, these are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cycloxygenase-2, COX-2, an enzyme responsible for inflammation and pain. Etoricoxib is a poorly soluble drug. To overcome this problem an attempt was made to prepare Etoricoxib solid lipid nanoparticles which has ability to improve the solubility and enhance oral bioavailability. In the present study Etoricoxib loaded SLNs were prepared by Hot homogenization method. Different formulations of Solid lipid nanoparticles of Etoricoxib were prepared by employing Glyceryl Monostearate as a solid lipid, Soya lecithin as lipophilic surfactant and Gelucire 48/16 as hydrophilic surfactant. The evaluation studies like drug content, entrapment efficiency and drug release studies, Particle size analysis, zeta potential, were performed on the prepared formulations. Among all the prepared formulations E2 formulation was found to show better results.