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Gastrodin from TCM Tianma for Pteridine Pathway Enhancement via ALDH7A1 Modulation

descriptionPublicationkeyboard_double_arrow_right Preprint Under curationPublisher:Zenodo
Authors: MedicOath Autonomous Discovery Engine;

doi: 10.5281/zenodo.19832852

Gastrodin from TCM Tianma for Pteridine Pathway Enhancement via ALDH7A1 Modulation

Abstract

Gastrodin, the primary bioactive compound from Gastrodia elata (Tianma), enhances aldehyde dehydrogenase ALDH7A1 activity and promotes folate-pteridine cofactor recycling. The compound upregulates sepiapterin reductase expression through CREB phosphorylation, potentially bypassing deficient 6-pyruvoyl-tetrahydropterin synthase activity by enhancing downstream BH4 synthesis pathways.

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