Schiff‍‌‍‍‌ bases are one of the most common imine derivatives that are prepared by the reaction of primary amines with aldehydes or ketones and contain the azomethine (C=N,) group. In this paper, simple and low-cost lab methods were used to synthesize, characterize, and test the Schiff bases derived from carbonyl‍‌‍‍‌ compounds. The reactions were carried out under mild conditions using ethanol as a solvent and a few glacial acetic acids as a catalyst to form solid Schiff bases, which are purified by the process of recrystallization. The‍‌‍‍‌ synthesized Schiff bases were analysed for their physical properties. Solubility and Melting point are the two properties that give an indication of the purity and stability of the Schiff‍‌‍‍‌ bases. Structural characterization was done using spectral analysis, where the characteristic imine absorption bands appear and confirm the formation of Schiff base. Thin layer chromatography is used to check the progress of the reaction and purity. Chemical identification tests such as Schiff reagent test and 2, 4-dinitrophenylhydrazine test are conducted and gave negative results, which indicate the absence of unreacted carbonyl groups. Biological evaluation is done by antimicrobial tests to check whether the compound is potentially active or not