Purpose: To analyze the ocular adverse effects induced by psychotropic medications and describe their mechanisms according to drug classes. Methods: A retrospective descriptive study involving 20 patients followed between January 2023 and June 2025 for ocular manifestations secondary to psychotropic therapy. Results: The mean age was 49 years (18–72), with a female predominance (60%). Neuroleptics accounted for 40% of prescriptions, antidepressants for 30%, anxiolytics for 20%, and mood stabilizers for 10%. The most frequent ocular effects were dry eye (45%), accommodative disorders (25%), ocular hypertension or acute glaucoma (15%), corneal deposits (10%), and retinal changes (5%). Conclusion: Psychotropic drugs may cause a wide range of ocular side effects. Early detection and collaboration between psychiatrists and ophthalmologists are essential to prevent visual complications.