The 13th edition of the Venice Training School 2025, took place from 9th to 13th June 2025. Under the motto “Innovating with Purpose: A Hands-on Journey into Functional, Safe and Sustainable Advanced Materials”, it focused on advancing knowledge and practice in Safe-and-Sustainable-by-Design (SSbD) assessment and decision-making for advanced materials (AdMa) and chemicals, and explore cutting-edge methodologies for ensuring the safety, functionality, and sustainability of innovative materials. Jointly organised by the EU funded projects AlChemiSSts, BIOSAFIRE, CheMatSustain, CHIASMA, DESIDERATA, EuMINe Cost Action, INSIGHT, INTEGRANO, MACRAMÉ, PINK, PLANETS, POTENTIAL, REPOXYBLE, SiToLub, SSbD4CheM, SUNRISE, SUPREME, SURPASS, supported by the Ca' Foscari University Venice, and having the Network for Safety and sustainability of Chemicals and materials (NSC) as a special partner, this edition of the school brought in international perspectives on a number of topics, featured interesting lectures and practical hands-on sessions, aiming to foster an integrative understanding of the school's topics, providing an interactive learning environment and direct access to key experts. Finally, networking activities allowed for plenty of time and opportunities to expand networks and foster academic exchange. Recordings are available on the NSC YouTube channel – Playlist Venice School 2025