Abstract ENThis document, produced with the assistance of ChatGPT o3 and GPT-5 Thinking, is released under the Apache 2.0 license. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC/CPI Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). It consolidates 100 enabling embodiments spanning gold nanomedicine (photothermal ablation, CRISPR-Gold delivery, nanozymes, theranostics), whole-body sensing (MRI, OPM/EEG, exposome), imaging/reconstruction (photoacoustics, DECT, PCD-CT), AI (digital twins, safety-constrained bandits/RL, federated/split learning, HE/TEE privacy), closed-loop neuromodulation and perfusion, GMP manufacturing/QA, packaging and traceability. Each item includes reproducible parameters (materials, device specs, acquisition, dosing, QA/PAT) and at least one IPC and one CPC classification, enabling practitioners to implement and thereby pre-empt narrow patents. Timestamp proof (RFC 3161 / FreeTSA) may be attached; cryptographic hash (SHA-256) is provided below. Résumé FRCe document, produit avec l’assistance de ChatGPT o3 et GPT-5 Thinking, est diffusé sous licence Apache 2.0. Il constitue une publication défensive volontaire (antériorité) et entre, dès sa diffusion publique, dans l’art antérieur au titre des régimes suivants : CBE art. 54(2), CPI art. L 611-11, 35 U.S.C. §102(a), Loi chinoise sur les brevets art. 22(5) (中华人民共和国专利法), et Loi japonaise sur les brevets art. 29(1) (特許法). Il regroupe 100 mises en œuvre « enabling » couvrant la nanomédecine à base d’or (photothermie, CRISPR-Gold, nanozymes, théranostique), le scan corps entier (IRM, OPM/EEG, exposome), l’imagerie/reconstruction (photoacoustique, DECT, CT à comptage de photons), l’IA (jumeaux numériques, bandits/RL sûrs, fédéré/split learning, HE/TEE), les boucles fermées thérapeutiques, la fabrication/QA GMP, le packaging et la traçabilité. Chaque item fournit des paramètres reproductibles et au moins un code IPC et un code CPC, bloquant ainsi des revendications étroites. Une preuve d’horodatage (RFC 3161 / FreeTSA) et l’empreinte SHA-256 figurent ci-dessous. Timestamp: 2025-09-20T09:44:29ZSHA-256: 240951f01a8c0d61e058db7ac12415b4426676088bb3e13291d0216852473c88 Liste des innovations & classification (IPC ; CPC) NIR-guided AuNR photoablation — IPC A61B 18/20 ; CPC A61N 5/067 Endosomal-release CRISPR-Gold — IPC C12N 15/113 ; CPC C12N 15/1135 Anti-ROS Au nanozymes — IPC A61K 9/51 ; CPC B82Y 5/00 Telomerase-modulating AuNPs — IPC A61K 47/68 ; CPC A61P 43/00 pH-triggered CT/MRI theranostic — IPC A61K 49/12 ; CPC A61K 49/0046 CNM-Au8 bioenergetic dosing — IPC A61P 25/28 ; CPC A61K 9/127 Hepatotropic anti-inflammaging miRNA — IPC A61K 31/7088 ; CPC A61P 1/16 Conductive Au-nanowire hydrogel — IPC A61L 27/60 ; CPC C08L 89/00 AuNP-microbubble BBB with FUS — IPC A61N 7/00 ; CPC A61B 8/08 Continuous GMP AuNP microfluidics — IPC B01J 13/02 ; CPC B01L 3/5027 Lyophilized AuNP with cold-cap — IPC B65D 81/32 ; CPC A61J 1/20 Ligand density AuNP QC kit — IPC G01N 33/68 ; CPC C12Q 1/70 Whole-body MRI + self baseline AI — IPC G06T 7/73 ; CPC G16H 50/20 Private ear-EEG at edge — IPC A61B 5/0408 ; CPC G16H 40/63 Multimodal exposome badge — IPC G01N 15/06 ; CPC G16H 40/20 Hybrid ODE+ML digital twin — IPC G06N 20/00 ; CPC G16H 10/60 ECG-to-VNS closed loop — IPC A61N 1/36 ; CPC A61B 5/024 Biomarker-guided tACS for MDD — IPC A61N 1/32 ; CPC A61B 5/0402 Multistream federated learning — IPC G06F 21/62 ; CPC G16H 20/30 Interop layer FHIR/OMOP + consent — IPC G06F 16/946 ; CPC G16H 40/20 Uncertainty-aware clinical dashboard — IPC G06Q 50/22 ; CPC G16H 50/30 Healthcare MLOps drift/rollback — IPC G06F 11/36 ; CPC G16H 40/63 Telemetry cold-chain for AuNP — IPC B65D 81/38 ; CPC G06Q 10/083 Calibration-as-a-Service — IPC G01N 33/00 ; CPC G06Q 50/26 Hepatic implant port + NIR fiber — IPC A61M 25/00 ; CPC A61B 18/20 AuNP microneedle patch — IPC A61K 9/70 ; CPC A61M 37/0015 Physics-informed low-dose recon — IPC G06T 5/40 ; CPC A61B 6/03 $^{31}$P-MRS-driven CNM-Au8 titration — IPC A61B 5/055 ; CPC G16H 50/20 Multi-omic biological age panel — IPC C12Q 1/6886 ; CPC G01N 33/68 On-device digital phenotyping — IPC G06F 21/62 ; CPC G16H 40/63 Renal-clearable Au clusters — IPC A61K 49/12 ; CPC A61K 49/0046 RBC-membrane coated AuNP — IPC A61K 9/51 ; CPC B82Y 5/00 Anti-senescent AuNP vaccine — IPC A61K 39/00 ; CPC A61P 43/00 Cross-site imaging domain adapt — IPC G06T 7/70 ; CPC G16H 50/20 Patient-adaptive k-space MRI — IPC A61B 5/055 ; CPC G01R 33/48 Clinically constrained synthetic data — IPC G06N 20/00 ; CPC G16H 10/60 Zero-knowledge consent ledger — IPC G06F 21/62 ; CPC G16H 40/20 In vivo Au quant by DECT — IPC A61B 6/03 ; CPC A61B 6/544 Inline depyrogenation for AuNP — IPC B01D 61/44 ; CPC B01D 61/4412 Aseptic fill-finish with PAT — IPC B65B 59/00 ; CPC B65B 59/04 Intranasal mucoadhesive AuNP — IPC A61K 9/08 ; CPC A61K 9/0012 Pressure-threshold IA perfusion — IPC A61M 25/00 ; CPC A61M 25/007 DCE-MRI guided photothermy — IPC A61N 5/067 ; CPC A61B 5/055 Saliva TRAP lateral flow — IPC C12Q 1/6886 ; CPC G01N 33/68 Anti-amyloid aptamer AuNP — IPC A61K 47/68 ; CPC A61P 25/28 Portable NV-diamond MEG — IPC A61B 5/06 ; CPC G01R 33/02 EEG dictionary compression — IPC A61B 5/0408 ; CPC G16H 40/63 Fast clinical 31P-MRS NAD+ — IPC A61B 5/055 ; CPC G01R 33/48 Photonic tamper-evident seal — IPC B65D 55/00 ; CPC G09F 3/03 Safe therapeutic NIR pen — IPC A61N 5/067 ; CPC A61B 18/20 Two-photon PA-guided nanostars — IPC A61N 5/06 ; CPC A61N 5/067 Exosome-coated AuNP — IPC A61K 35/12 ; CPC A61K 2035/547 Janus Au–Fe3O4 magneto-NIR — IPC A61N 2/02 ; CPC A61N 2/02 198Au radiotherapeutic NPs — IPC A61K 51/10 ; CPC A61K 51/04 Nanoshells + ICG combo — IPC A61K 33/30 ; CPC A61P 35/00 Nebulized AuNP-liposomes — IPC A61M 15/00 ; CPC A61M 15/008 Smartphone LSPR microRNA test — IPC G01N 21/64 ; CPC C12Q 1/6809 Sweat IL-6/cortisol patch — IPC A61B 5/145 ; CPC G01N 33/68 Spectro-lock syringe — IPC A61M 5/32 ; CPC G01N 21/64 DECT-PK AUC dosing — IPC G06N 20/00 ; CPC G16H 50/20 Ontologized feature store — IPC G06F 16/946 ; CPC G16H 10/60 Differentially private TS generator — IPC G06N 20/00 ; CPC G16H 10/60 Guarded HIFU-PA probe — IPC A61N 7/00 ; CPC A61B 8/14 Multi-organ perfusion robot — IPC A61M 25/00 ; CPC A61M 25/0094 Opto-microneedle Au patch — IPC A61M 37/00 ; CPC A61N 5/067 Photoacoustic tomography of AuNP — IPC A61B 8/14 ; CPC A61B 8/523 SoS-adaptive PA reconstruction — IPC G06T 7/60 ; CPC G16H 50/20 Clinical TEE inference — IPC G06F 21/55 ; CPC G16H 40/63 N2 headspace + O2 scavenger — IPC B65D 81/26 ; CPC A61J 1/20 GMP nano line digital twin — IPC G09B 23/28 ; CPC G05B 19/418 Au nanocages with PCM — IPC A61K 9/51 ; CPC B82Y 5/00 Sequenced AuNP + anti-PD-1 — IPC A61K 39/395 ; CPC A61P 35/00 SERS SASP blood barcodes — IPC G01N 21/65 ; CPC C12Q 1/6886 Photon-counting CT gold quant — IPC A61B 6/03 ; CPC A61B 6/5415 Platelet-membrane AuNP — IPC A61K 9/51 ; CPC B82Y 5/00 Neutrophil-membrane AuNP — IPC A61K 9/51 ; CPC A61P 31/04 Au helical microrobots — IPC A61B 34/10 ; CPC A61B 34/20 Intravitreal Au-anti-VEGF — IPC A61F 9/007 ; CPC A61K 9/00 Antibacterial Au implant coating — IPC A61L 27/56 ; CPC A61F 2/28 Peri-implant NIR fiber — IPC A61B 18/20 ; CPC A61N 5/067 AuNP barrier organ-on-chip — IPC B01L 3/5023 ; CPC G01N 33/50 SERS endoscope for margins — IPC A61B 1/00 ; CPC G01N 21/64 Photobiomodulation wound patch — IPC A61L 15/44 ; CPC A61N 5/067 Contextual-bandit combo therapy — IPC G06N 20/00 ; CPC G16H 50/20 Safe-RL dosing for CRISPR-Gold — IPC G06N 20/00 ; CPC G16H 50/30 Clinical AI fairness audit — IPC G06F 21/62 ; CPC G16H 40/63 Semi-synthetic omic data — IPC G06N 20/00 ; CPC G16H 10/60 Dynamic consent UX — IPC G06F 21/62 ; CPC G16H 40/20 Split learning multimodal — IPC G06F 16/946 ; CPC G16H 10/60 Lightweight HE inference — IPC G06F 21/62 ; CPC G16H 40/63 Wearable OPM magnetocardiography — IPC A61B 5/06 ; CPC G01R 33/02 Personalized vectorcardio AI — IPC G06T 7/73 ; CPC G16H 50/20 Whole-body OPM bioelectric map — IPC A61B 5/05 ; CPC G01R 33/02 Ultrasound patch network trigger — IPC A61B 8/00 ; CPC A61N 7/00 Photoacoustic vascular-age ring — IPC A61B 8/14 ; CPC A61B 8/523 Inline GMP exosome coating — IPC B01D 61/44 ; CPC A61K 35/12 Residual surfactant GC-MS — IPC G01N 30/88 ; CPC B01D 15/08 Validated e-beam sterilization — IPC A61L 2/08 ; CPC A61L 2/26 GS1 UDI serialization for AuNP — IPC G06Q 10/08 ; CPC G06Q 10/083 Thermo-dosimetric treatment plan — IPC G06F 17/50 ; CPC G16H 50/20 Keywords gold nanoparticle, photothermal therapy, CRISPR delivery, nanozyme, telomerase modulation, theranostic, dual-modality imaging, NAD+ metabolism, hepatotropic targeting, anti-inflammaging, conductive hydrogel, nerve regeneration, BBB opening, focused ultrasound, microfluidics, GMP QC, lyophilization, cold chain, ligand density assay, whole-body MRI, self-supervised learning, digital twin, closed-loop stimulation, vagal nerve stimulation, tACS, federated learning, differential privacy, FHIR interoperability, clinical dashboard, explainability, MLOps, model drift, traceability, implantable port, microneedle patch, low-dose reconstruction, 31P-MRS, epigenetic clock, metabolomics, HRV, digital phenotyping, on-device AI, renal-clearable gold, RBC membrane coating, senescence vaccine, domain adaptation, harmonization, adaptive k-space, compressed sensing MRI, synthetic clinical data, diffusion model, zero-knowledge proofs, consent ledger, dual-energy CT, calibration phantom, endotoxin removal, AEX membrane, fill-finish isolator, process analytical tech, intranasal delivery, mucoadhesive, pressure-gated perfusion, DCE-MRI control, lateral flow assay, telomerase TRAP, anti-amyloid aptamer, NV magnetometer, wearable MEG, EEG compression, edge codec, fast 31P-MRS, tamper-evident seal, fiber Bragg grating, NIR pen, photobiomodulation, nanostar ablation, two-photon laser, photoacoustic guidance, exosome coating, macrophage polarization, janus nanoparticle, magnetothermal therapy, 198Au radiotherapy, dosimetry MIRD, nanoshell ICG, photodynamic synergy, nebulized liposome, pulmonary delivery, LSPR assay, microRNA plasma, sweat patch, aptamer sensor, cortisol MIP, inline spectroscopy, smart syringe, DECT PK dosing, feature store, ontology FHIR, synthetic time series, trusted execution, remote attestation, oxygen scavenger, optode sensor, GMP digital twin, process PAT