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Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth: Supplementary Files

Authors: Creasey, Nicole; Neumann, Alexander;

Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth: Supplementary Files

Abstract

Supplementary file for "Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth". Table S1. Regression results for family birthweight polygenic scores predicting child birthweight (grams) adjusted for the polygenic scores or other family members based on three types of model (duo, trio, partitioned effects) Table S2. Regression results for the methylation profile score (MPS, in SD) or DNA methylation sites (M-values) predicting child birthweight (grams) Table S3. Mother-child duo regression results for child and mother birthweight polygenic scores predicting DNAm at birthweight-associated CpG loci adjusted or unadjusted for the polygenic score of the other family member Table S4. Trio regression results for child, mother and father birthweight polygenic scores predicting DNAm at birthweight-associated CpG loci adjusted or unadjusted for the polygenic score of the other family members Table S5. A priori GWAS adjusted duo regression results for fetal-effect and maternal-effect birthweight polygenic scores predicting DNAm at birthweight-associated CpG loci adjusted or unadjusted for the polygenic score of the other family member Table S6. Annotation Table S7. Sex-interaction analysis with observed birthweight as outcome Table S8. Sex-interaction analysis based on a priori GWAS adjusted duo regression models predicting DNA methylation. Table S9. Mediation of fetal- or maternal-effect PGS on observed birthweight or DNA methylation via prenatal health factors (Standardized estimates) Table S10. Mediation of fetal- or maternal-effect PGS on observed birthweight via DNA methylation

Related Organizations
Keywords

Birth Weight, Epigenetics, DNA Methylation, Pediatrics, Genetic Risk Score/epidemiology

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average