The MYRIAD-EU project responds to the growing need for comprehensive frameworks to assessand manage risks arising from multi-hazard and multi-sectoral interactions. While multi-hazardevents account for a minority of disaster records, they are responsible for a disproportionate shareof global economic losses, highlighting the limitations of traditional single-hazard approaches. Toaddress this, MYRIAD-EU developed and tested a flexible, integrative framework for multi-hazard,multi-risk, and systemic risk management across five diverse European pilot regions. This reportpresents the final version of the MYRIAD-EU framework and accompanying guidance protocols,refined through four years of implementation and iterative feedback. Drawing on documentreviews, survey responses, and focus group discussions with pilots, the report synthesizes keylessons from operationalizing the framework and outlines updates that enhance its usability andapplicability. The deliverable serves as a practical resource for stakeholders seeking to integratemulti-hazard risk considerations into disaster risk reduction planning and decision-making.