This info kit aims to provide an essential information package for the research community to engage with key stakeholders in the realm of in silico medicine. It provides guidelines on effective stakeholder interaction and includes information material, multimedia communication examples, focus group methodologies, surveys, and beyond. This document aims to empower researchers with a wealth of instructions and resources for navigating the complexities of in silico medicine stakeholder engagement. In light of the above stated aims, the first version of this info kit primarily includes materials that facilitate efficient dialogue with patient organisations and patients themselves, as well as clinicians and other healthcare professionals - which are amongst the primary stakeholder groups for in silico medicine. In the subsequent phases, we envision broadening the scope of this info kit by including tools and resources that facilitate engagement with other groups of stakeholders. The document is developed by the Virtual Physiological Human Institute (VPHi), an international non-profit organisation whose mission is to ensure that the potential of in silico medicine is fully realised, its tools universally adopted and efficiently used in both research and clinical practice. This info kit is a living document and, hence, will undergo regular updates, ensuring that the latest advancements in the field of in silico medicine are consistently reflected. Every community member and stakeholder is welcome to contribute to this document. We appreciate and look forward to the developments and contributions of the research community, clinicians, patients, and other key players. This work is developed as part of the EU-funded projects SimCardioTest (H2020-SC1-DTH-2020-1, GA 101016496) and In Silico World DTH-2020-1, GA 101016503). (H2020-SC1The resources included have been developed in the scope of said projects, as well as others, such as EDITH 101083771) and SimCor (DIGITAL-2021-DEPLOY-01-TWINS-HEALTH, GA (H2020-SC1-DTH-2020-1, GA 101017578). To request further information, or if you are willing to contribute to this initiative, please email admin@vph-institute.org