Abstract: Religion and spirituality have long been recognized as integral to human existence, providing comfort, hope, and meaning—particularly during times of psychological distress. As mental health nursing embraces holistic care, understanding the role of religion and spirituality becomes crucial. This review explores how spiritual beliefs influence mental health outcomes, the challenges in integrating spiritual care into psychiatric practice, and the competencies nurses require to support clients' spiritual needs. By analyzing current literature, nursing models, and practical strategies, this article advocates for culturally competent, spiritually sensitive mental health care.