CT video of a human cranium with lytic lesions belonging to the human remains designated as UE 6108. The remains were exhumed from a primary burial associated with the burial grounds of the 3rd Order of Our Lady of Carmo in Porto, Portugal. You may find the complete bioanthropological report at: Vassallo, S., Assis, S., Santana, A., & Alves Cardoso, F. (2025). Bioanthropological analysis report of the human remains identified as UE 6108: Carmo burial site. Zenodo. https://doi.org/10.5281/zenodo.15299304. Disclaimer: This is a video of a human cranium. It was undertaken as part of scientific research and assessment of the remains to support its bioanthropological analysis. Please do not decontextualise the video. If you choose to use it for scientific purposes or as a teaching aid please be mindful that these are human remains. This video is licensed with a Creative Commons License CC BY-NC-ND 4.0. If you have concerns, you may reach the BeFRAIL project Principal Investigator at: francicard@fcsh.unl.pt.