Rhodanine and its derivatives are very important aspect in medicinal point of view. That creates huge interest among researcher to do various research regarding rhodanine. In the present study we have studied various synthesis techniques used in the literature to synthesize rhodanine and its derivatives including various reactions. These materials have gained much interest of researchers due to its variety of applications in biomedical and pharmaceutical fields. The Rhodanine has been synthesized by various techniques having their own advantages and disadvantages. Since, the Knoevenagel condensation gives good yield and have many advantages over other techniques. This condensation helps to obtain various derivatives of Rhodanine.