Abstract: Polycystic Ovary Syndrome (PCOS) is one of the most prevalent endocrine disorders affecting women of reproductive age. It is characterized by hormonal imbalances, metabolic dysfunction, and reproductive irregularities, significantly impacting women's physical and mental well-being. Nurses play a crucial role in providing holistic care to women with PCOS by offering patient education, lifestyle guidance, mental health support, and interdisciplinary collaboration. This review explores the pathophysiology, clinical manifestations, diagnostic criteria, and holistic management of PCOS, emphasizing the nurse’s role in improving patient outcomes.