Abstract: Pregnancy is a transformative journey marked by profound physiological, hormonal, and psychological changes that support fetal development. While these changes are crucial for sustaining pregnancy, they often lead to various discomforts that impact a woman’s physical health, emotional well-being, and daily functioning. Common pregnancy-related discomforts include nausea, vomiting, fatigue, heartburn, back pain, leg cramps, edema, frequent urination, and sleep disturbances. Although these discomforts are generally temporary, they can cause significant distress if not properly managed. Nurses play a pivotal role in identifying, educating, and managing these discomforts through evidence-based practices, non-pharmacological interventions, and patient-centered care. Nursing interventions focus on symptom relief, lifestyle modifications, dietary adjustments, and emotional support to ensure maternal well-being. This article provides a comprehensive review of common pregnancy discomforts, their causes, and effective nursing interventions aimed at enhancing maternal comfort and quality of life.