The widespread acceptance of the cloud-native concept and the emergence of several specialized cloud-native apps have focused industry attention on the web stacks of cloud-native apps. The integration of cloud-native and full-stack development tools allows for the rapid and smooth deployment, scaling, and maintenance of web applications. Full stack development today in the cloud native era is a hybrid of its technologies and ways of working to bring about scalability, efficiency and maintainability. Built in tools like AWS Amplify, Google Firebase, Heroku can be used for a smooth deployment; serverless computing (AWS Lambda, Google Cloud Functions) also cuts out all the overhead from infrastructure management. Moving applications to Dockerized containers that are supervised in Kubernetes leads to portability and consistency of applications across environments. The whole stack presents include different front-end frameworks (React, Angular), back-end technologies (Node.js, Django), and cloud-based databases (MongoDB, AWS DynamoDB) for making robust web applications. Furthermore, DevOps practices, CI/CD pipelines, and Infrastructure as Code (IaC) help with deployment, monitoring and scaling which makes the operation more efficient. Because cloud-native architecture is modularity and resilience-oriented, it provides some microservices and API-driven interactions. Despite the problems of emerge, such as security vulnerabilities and performance bottlenecks, best practices like containerization, serverless computing, and also the database optimization make possible reliable, scalable and secure cloud applications. In this paper, a modern full stack development approach is explored, including key technologies, challenges and solutions to increase the performance and maintenance in cloud-based environment.