This paper delves into the transformative intersection of nuclear physics, particle dynamics, and nanotechnology to tackle major global challenges such as energy sustainability, advancements in healthcare, and environmental remediation. It comprehensively examines how nanotechnology has revolutionized nuclear reactor designs, enhanced fuel efficiency, and improved radiation safety through innovations like nanostructured fuels, advanced thermal management using nanofluids, and radiation-resistant materials. The application of nanotechnology in nuclear medicine and radiotherapy has paved the way for precision-focused diagnostics and treatments, with groundbreaking developments like nanoparticle-based imaging agents and radiosensitizers. Furthermore, the study explores cutting-edge uses of nanomaterials in nuclear waste recycling, environmental cleanup, and isotope production, highlighting their role in enhancing efficiency, minimizing waste, and recovering valuable resources. Nanotechnology's contributions to advanced radiation detection systems, wearable dosimeters, and sustainable protective materials further bolster safety in high-radiation environments. While acknowledging challenges such as scalability, long-term stability, and regulatory hurdles, the paper emphasizes future directions that integrate interdisciplinary collaboration, environmentally friendly synthesis techniques, and AI-driven optimization to unlock the full potential of nanotechnology in these domains. By synthesizing these fields, this research not only propels scientific innovation but also aligns with global efforts to create sustainable, health-centric solutions, demonstrating the immense societal benefits of merging nuclear science and nanotechnology.