This archive makes available accessibility indicators at EU scale from populated 1km EU grid to towns and cities at EU scale (512 million travel time by car calculated between origins and destinations). It follows a reproducible, transparent and updatable framework. It uses only open source and free routing engines (OSRM), based on OpenStreetMap (OSM) network. This routing engine makes possible the creation of travel time indicators for a large set of origins and destinations. The EU towns and cities layer has been recently made available and named by the European Commission. This layer is based on a common methodology for all Europe. Within GRANULAR activities, we consider the towns and cities layer as a proxy to discuss on little and medium commercial centralities in Europe. This methodological framework, implemented with open source solutions (data and code) only and documented in a reproducible way in R notebooks, could be easily extended to other origins and destinations, if a relevant layer will be identified in the future. Based on travel time matrix, it is possible to compute a large set of indicators. This archive (see readme at the root folder) describes the input data used, summarises the data processing and provide information and metadata on output indicators created at 1km grid cells. All the output data is also available.