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ZENODO
Dataset . 2018
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2018
License: CC BY
Data sources: Datacite
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ZENODO
Dataset . 2018
License: CC BY
Data sources: Datacite
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The Process Of Hdac11 Assay Development: Time-Course Study

Research datakeyboard_double_arrow_right Dataset 09 Mar 2018Publisher:Zenodo
Authors: Abbey, Megha; Vedadi, Masoud;

doi: 10.5281/zenodo.1195031 , 10.5281/zenodo.1195030 , 10.5281/zenodo.1304260

The Process Of Hdac11 Assay Development: Time-Course Study

Abstract

The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

Using Boc-Lys-(TFA)-AMC substrate, a preliminary time-course study was initiated to determine the appropriate HDAC11 concentration and the time to be used for the reaction (which are essential parameters to perform Km calculations later).

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Keywords

assay development, HDAC, HDAC11, Boc-Lys-(TFA)-AMC, time-course, Boc-Lys-(TFA), burst kinetics, pre-steady state, trifluoroacetate, enzyme activity

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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