Objectives: The present study was to evaluate and compared the Ophthalmic manifestations of patients between methicillin resistant Staphylococcus aureus (MRSA) and methicillin sensitive Staphylococcus aureus (MSSA) in a tertiary care center, Patna, Bihar, India. Methods: We determined susceptibility of the isolates to seven antibiotics (oxacillin, penicillin, erythromycin, clindamycin, trimethoprim/sulfamethoxazole, vancomycin and teicoplanin) using the disc diffusion method according to the Clinical and Laboratory Standard Institute (CLSI) standards for antimicrobial susceptibility testing. We used oxacillin to test for b-lactam antibiotic resistance. We reviewed patient charts to collect demographic and clinical information. Results: Health exposure for ocular infection in MRSA patients was 11(36.66%) and in MSSA was 8(22.85%). It was not significant differences (p=0.22). Clinical Diagnoses Associated with Ocular MRSA and MSSA ocular had Keratitis 12(40%) and 15(42.85%) respectively, which was not significant differences (p=0.817). Conjunctivitis, lacrimal system disorder, wound infection, endophthalmitis, vision threatening disorder and others in MRSA and MSSA patients was not significant differences (p>0.05). But the lid disorder in MRSA and MSSA patients was significant differences (p=0.033). Erythromycin and clindamycin in MRSA and MSSA patient were highly significant differences (p=<0.0001). Penicillin and Sulfamethoxazole/Trimethoprim in MRSA and MSSA was significantly differences (p=0.057). MRSA was significantly more resistant than MSSA to several antibiotics including erythromycin, clindamycin, penicillin and sulfamethoxazole/trimethoprim. 83.33% of MRSA isolates were susceptible to sulfamethoxazole/trimethoprim. Conclusions: All MRSA isolates are susceptible to vancomycin and teicoplanin. MRSA is common in ocular Staphylococcus aureus infection in our tertiary care centre. Hence, Infectious diseases may differ by regions in epidemiologic patterns, spectrum and severity of disease, and profiles of antibiotic susceptibility.

Objectives: The present study was to evaluate and compared the Ophthalmic manifestations of patients between methicillin resistant Staphylococcus aureus (MRSA) and methicillin sensitive Staphylococcus aureus (MSSA) in a tertiary care center, Patna, Bihar, India. Methods: We determined susceptibility of the isolates to seven antibiotics (oxacillin, penicillin, erythromycin, clindamycin, trimethoprim/sulfamethoxazole, vancomycin and teicoplanin) using the disc diffusion method according to the Clinical and Laboratory Standard Institute (CLSI) standards for antimicrobial susceptibility testing. We used oxacillin to test for b-lactam antibiotic resistance. We reviewed patient charts to collect demographic and clinical information. Results: Health exposure for ocular infection in MRSA patients was 11(36.66%) and in MSSA was 8(22.85%). It was not significant differences (p=0.22). Clinical Diagnoses Associated with Ocular MRSA and MSSA ocular had Keratitis 12(40%) and 15(42.85%) respectively, which was not significant differences (p=0.817). Conjunctivitis, lacrimal system disorder, wound infection, endophthalmitis, vision threatening disorder and others in MRSA and MSSA patients was not significant differences (p>0.05). But the lid disorder in MRSA and MSSA patients was significant differences (p=0.033). Erythromycin and clindamycin in MRSA and MSSA patient were highly significant differences (p=<0.0001). Penicillin and Sulfamethoxazole/Trimethoprim in MRSA and MSSA was significantly differences (p=0.057). MRSA was significantly more resistant than MSSA to several antibiotics including erythromycin, clindamycin, penicillin and sulfamethoxazole/trimethoprim. 83.33% of MRSA isolates were susceptible to sulfamethoxazole/trimethoprim. Conclusions: All MRSA isolates are susceptible to vancomycin and teicoplanin. MRSA is common in ocular Staphylococcus aureus infection in our tertiary care centre. Hence, Infectious diseases may differ by regions in epidemiologic patterns, spectrum and severity of disease, and profiles of antibiotic susceptibility.