Why do we need Safe and Sustainable Design of innovative advanced materials? The current situation serves as a compelling reason to prioritize activities in accordance with the needs outlined in this roadmap, with the aim of averting a future where we are constantly playing catch-up due to past ignorance. Instead, we should strive to achieve a successful transformation towards a safe and sustainable,toxic-free world. (Version 2 includes the project acknowledgements and minor revisions) (Version 3 incorporates revisions to Figure 2) (Version 4 contains minor revisions in the text)