Needle free injection system are to introduce the various medicines into patients without piercing the skin with a conventional needle. Needle-free technology offers the many benefit of reducing patient concern about the use of needle. Needle free injection is the very effective injections a wide range of drugs and bioequivalent to syringe and needle. It results in less pain, and is strongly preferred by patients. Additional benefits include very fast injection compared with conventional needles and no needle disposal issues. Not only benefit of the pharmaceutical industry to the increasing product sales, it has the added potential to increase compliance with dosage regimens and improved outcomes. Today, they are a steadily developing technology that promises to make the administration of medicine more efficient and less painful. Keywords: NFID ,Injection, Skin, Subcutaneous, Pressure