According to published archaeological sources, zooarchaeological data collection on the Qinghai-Tibet Plateau and its marginal and transitional areas is inadequate, and relevant datasets have not been published. For this reason, we collected and collated relevant information. Our database provides the geographical location, elevation, cultural type and faunal assemblage of each site on the Qinghai-Tibet Plateau and its periphery for which zooarchaeological data have been published from the Paleolithic to the Early Iron Age. The patterns of human faunal resource use, habitat patterns, and animal abundance and spatial distribution on the Qinghai-Tibet Plateau and its surrounding areas during the Prehistoric-Early Iron Age are represented in this dataset. The data provide a reference for further understanding prehistoric-early Iron Age human behavior, subsistence patterns and material and cultural exchanges between East and West on the Qinghai-Tibet Plateau and its environs.