Interfering with Apoptosis: Ca  2+  -Binding Protein ALG-2 and Alzheimer's Disease Gene  ALG-3

descriptionPublicationkeyboard_double_arrow_right Article 26 Jan 1996 Italy English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 271, pages 521-525 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Vito P; LACANA E; D'ADAMIO, LUCIANO;

doi: 10.1126/science.271.5248.521

pmid: 8560270

handle: 11588/138252

Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

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Abstract

Two apoptosis-linked genes, named ALG-2 and ALG-3 , were identified by means of a functional selection strategy. ALG-2 codes for a Ca 2+ -binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3 , a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2 , rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca 2+ -regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.

Country

Italy

Related Organizations

National Institutes of Health
United States
National Institute of Allergy and Infectious Diseases
United States
University Federico II of Naples
Italy
National Institute of Health
Pakistan

Keywords

DNA, Complementary, Fas Ligand Protein, Hybridomas, Membrane Glycoproteins, Calcium-Binding Proteins, Molecular Sequence Data, Membrane Proteins, Apoptosis, Dexamethasone, Cell Line, Mice, Alkaloids, Alzheimer Disease, Dactinomycin, Animals, Interleukin-2, Calcium, Amino Acid Sequence, Cloning, Molecular, Apoptosis Regulatory Proteins

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