The relationship between epidermal growth factor receptor (EGFR) expression and tumor hypoxia has been extensively studied in various types of cancer. Research has shown that overexpression of EGFR and tumor hypoxia are associated with poor outcomes in head-and-neck squamous cell carcinoma. The underlying mechanisms are complex and involve multiple signaling pathways. Understanding the role of EGFR in tumor hypoxia is crucial for developing effective therapeutic strategies. This research aims to investigate the impact of EGFR expression on tumor hypoxia and its consequences on cancer progression.