research data . Dataset . 2016

Reassessment of CXCR4 Chemokine Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-2

Fischer, Thomas; Nagel, Falko; Jacobs, Stefan; Stumm, Ralf; Schulz, Stefan;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><h3>Background</h3><p>The CXCR4 chemokine receptor regulates migration and homing of cancer cells to specific metastatic sites. Determination of the CXCR4 receptor status will provide predictive information for disease prognosis and possible therapeutic intervention. However, previous attempts to localize CXCR4 using poorly characterized mouse monoclonal or rabbit polyclonal antibodies have produced predominant nuclear and occasional cytoplasmic staining but did not result in the identification of bona fide cell surface receptors.</p><h3>Methodology/Principal Findings</h3><p>In the present study, we extensively characterized the novel rabbit monoclonal anti...
Subjects
free text keywords: Neuroscience, Pharmacology, Immunology, Developmental Biology, Cancer, reassessment, cxcr4, chemokine, receptor, neoplastic, tissues, monoclonal, antibody, umb-2
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Dataset . 2016
Provider: figshare
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