research data . Dataset . 2014

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Open Access
  • Published: 02 Jan 2014
<div><p>There is no effective vaccine against Buruli ulcer. In experimental footpad infection of C57BL/6 mice with <i>M. ulcerans</i>, a prime-boost vaccination protocol using plasmid DNA encoding mycolyltransferase Ag85A of <i>M. ulcerans</i> and a homologous protein boost has shown significant, albeit transient protection, comparable to the one induced by <i>M. bovis</i> BCG. The mycolactone toxin is an obvious candidate for a vaccine, but by virtue of its chemical structure, this toxin is not immunogenic in itself. However, antibodies against some of the polyketide synthase domains involved in mycolactone synthesis, were found in Buruli ulcer patients and hea...
free text keywords: Biological Sciences, plasmid, dna, encoding, mycolactone, polyketide, synthase, domains, infected, mice
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Dataset . 2014
Provider: figshare
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