research data . Dataset . 2016

Immune Activation in the Female Genital Tract: Expression Profiles of Soluble Proteins in Women at High Risk for HIV Infection

C. Francis, Suzanna; Hou, Yanwen; Baisley, Kathy; van de Wijgert, Janneke; Watson-Jones, Deborah; T. Ao, Trong; Herrera, Carolina; Maganja, Kaballa; Andreasen, Aura; Kapiga, Saidi; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Soluble cervicovaginal biomarkers of inflammation, immune activation and risk of HIV acquisition are needed to reliably assess the safety of new biomedical prevention strategies including vaccines and microbicides. However, a fuller understanding of expression profiles in women at high risk for HIV infection is crucial to the effective use of these potential biomarkers in Phase 3 trial settings. We have measured 45 soluble proteins and peptides in cervicovaginal lavage samples from 100 HIV negative women at high risk for HIV infection. Women were followed over one menstrual cycle to investigate modulation by hormonal contraception, menstrual cycle phase,...
Subjects
free text keywords: Medicine, Cell Biology, Biotechnology, Immunology, Cancer, 110309 Infectious Diseases, 60506 Virology, Computational Biology, 69999 Biological Sciences not elsewhere classified, 19999 Mathematical Sciences not elsewhere classified, HBD, MIP, DMPA, Phase 3 trial settings, HIV Infection Soluble cervicovaginal biomarkers, IgG 2. Women, cervicovaginal lavage samples, SLPI, HIV acquisition, HIV infection, TGF, IP, IL, Female Genital Tract, MCP
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Dataset . 2016
Provider: figshare
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