research data . Dataset . 2016

Spatial Stochastic Dynamics Enable Robust Cell Polarization

J. Lawson, Michael; Drawert, Brian; Khammash, Mustafa; Petzold, Linda; Yi, Tau-Mu;
Open Access
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Although cell polarity is an essential feature of living cells, it is far from being well-understood. Using a combination of computational modeling and biological experiments we closely examine an important prototype of cell polarity: the pheromone-induced formation of the yeast polarisome. Focusing on the role of noise and spatial heterogeneity, we develop and investigate two mechanistic spatial models of polarisome formation, one deterministic and the other stochastic, and compare the contrasting predictions of these two models against experimental phenotypes of wild-type and mutant cells. We find that the stochastic model can more robustly reproduce t...
Subjects
free text keywords: Biological Sciences, Information and Computing Sciences, Computational biology, systems biology, developmental biology, Model organisms, Yeast and fungal models, Saccharomyces cerevisiae, Computer modeling, Computerized simulations, stochastic, robust
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Dataset . 2016
Provider: figshare
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