research data . Dataset . 2016

Role of Palladin Phosphorylation by Extracellular Signal-Regulated Kinase in Cell Migration

Asano, Eri; Maeda, Masao; Hasegawa, Hitoki; Ito, Satoko; Hyodo, Toshinori; Yuan, Hong; Takahashi, Masahide; Hamaguchi, Michinari; Senga, Takeshi;
Open Access
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Phosphorylation of actin-binding proteins plays a pivotal role in the remodeling of the actin cytoskeleton to regulate cell migration. Palladin is an actin-binding protein that is phosphorylated by growth factor stimulation; however, the identity of the involved protein kinases remains elusive. In this study, we report that palladin is a novel substrate of extracellular signal-regulated kinase (ERK). Suppression of ERK activation by a chemical inhibitor reduced palladin phosphorylation, and expression of active MEK alone was sufficient for phosphorylation. In addition, an <em>in vitro</em> kinase assay demonstrated direct palladin phosphorylation by ERK....
Subjects
Medical Subject Headings: macromolecular substancesinorganic chemicalsenzymes and coenzymes (carbohydrates)bacteriaenvironment and public health
free text keywords: Biochemistry, Cell Biology, Molecular Biology, palladin, phosphorylation, extracellular, signal-regulated, kinase
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Dataset . 2016
Provider: figshare
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