research data . Dataset . 2016

No title available

Open Access
  • Published: 18 Jan 2016
Abstract
<div><p>How splicing factors are recruited to nascent transcripts in the nucleus in order to assemble spliceosomes on newly synthesised pre-mRNAs is unknown. To address this question, we compared the intranuclear trafficking kinetics of small nuclear ribonucleoprotein particles (snRNP) and non-snRNP proteins in the presence and absence of splicing activity. Photobleaching experiments clearly show that spliceosomal proteins move continuously throughout the entire nucleus independently of ongoing transcription or splicing. Using quantitative experimental data, a mathematical model was applied for spliceosome assembly and recycling in the nucleus. The model assumes...
Subjects
free text keywords: Cell Biology, Molecular Biology, Biological Sciences, stochastic, spliceosome, recycling, nucleus
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Dataset . 2016
Provider: figshare
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