research data . Dataset . 2016

Pathogenic E. coli Exploits SslE Mucinase Activity to Translocate through the Mucosal Barrier and Get Access to Host Cells

Valeri, Maria; Rossi Paccani, Silvia; Kasendra, Magdalena; Nesta, Barbara; Serino, Laura; Pizza, Mariagrazia; Soriani, Marco;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>SslE is a zinc-metalloprotease involved in the degradation of mucin substrates and recently proposed as a potential vaccine candidate against pathogenic <i>E. coli</i>. In this paper, by exploiting a human <i>in vitro</i> model of mucus-secreting cells, we demonstrated that bacteria expressing SslE have a metabolic benefit which results in an increased growth rate postulating the importance of this antigen in enhancing <i>E. coli</i> fitness. We also observed that SslE expression facilitates <i>E. coli</i> penetration of the mucus favouring bacteria adhesion to host cells. Moreover, we found that SslE-mediated opening of the mucosae contributed to the ac...
Subjects
free text keywords: Biological Sciences, coli access, mucosal barrier, target cells, Pathogenic E, neutrophil recruitment, growth rate postulating, colonization factor favouring E, Host Cells SslE, mucin substrates, mucus favouring bacteria adhesion, il, Host cells, coli Exploits SslE Mucinase Activity, SslE expression, coli penetration, vaccine candidate, coli fitness
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Dataset . 2016
Provider: figshare
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