research data . Dataset . 2016

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Open Access
  • Published: 18 Jan 2016
Abstract
<div><p><em>Trypanosoma brucei</em> is the causative agent of African sleeping sickness. The polyamine biosynthetic pathway has the distinction of being the target of the only clinically proven anti-trypanosomal drug with a known mechanism of action. Polyamines are essential for cell growth, and their metabolism is extensively regulated. However, trypanosomatids appear to lack the regulatory control mechanisms described in other eukaryotic cells. In <em>T. brucei,</em> S-adenosylmethionine decarboxylase (AdoMetDC) and ornithine decarboxylase (ODC) are required for the synthesis of polyamines and also for the unique redox-cofactor trypanothione. Further, trypanos...
Subjects
free text keywords: Biochemistry, Physics, regulated, allosteric, activator, polyamine, biosynthesis, african, trypanosomes
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Dataset . 2016
Provider: figshare
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