research data . Dataset . 2016

Molecular Phylogeny of a RING E3 Ubiquitin Ligase, Conserved in Eukaryotic Cells and Dominated by Homologous Components, the Muskelin/RanBPM/CTLH Complex

Francis, Ore; Han, Fujun; C. Adams, Josephine;
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Ubiquitination is an essential post-translational modification that regulates signalling and protein turnover in eukaryotic cells. Specificity of ubiquitination is driven by ubiquitin E3 ligases, many of which remain poorly understood. One such is the mammalian muskelin/RanBP9/CTLH complex that includes eight proteins, five of which (RanBP9/RanBPM, TWA1, MAEA, Rmnd5 and muskelin), share striking similarities of domain architecture and have been implicated in regulation of cell organisation. In budding yeast, the homologous GID complex acts to down-regulate gluconeogenesis. In both complexes, Rmnd5/GID2 corresponds to a RING ubiquitin ligase. To better un...
Subjects
free text keywords: Biological Sciences, phylogeny, e3, ubiquitin, conserved, eukaryotic, cells, dominated, homologous
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Dataset . 2016
Provider: figshare
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