research data . Dataset . 2017

Double Digest RADseq: An Inexpensive Method for De Novo SNP Discovery and Genotyping in Model and Non-Model Species

K. Peterson, Brant; N. Weber, Jesse; H. Kay, Emily; S. Fisher, Heidi; E. Hoekstra, Hopi;
Open Access
  • Published: 01 Jan 2017
  • Publisher: Figshare
Abstract
<div><p>The ability to efficiently and accurately determine genotypes is a keystone technology in modern genetics, crucial to studies ranging from clinical diagnostics, to genotype-phenotype association, to reconstruction of ancestry and the detection of selection. To date, high capacity, low cost genotyping has been largely achieved via “SNP chip” microarray-based platforms which require substantial prior knowledge of both genome sequence and variability, and once designed are suitable only for those targeted variable nucleotide sites. This method introduces substantial ascertainment bias and inherently precludes detection of rare or population-specific variant...
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doi: 10.1371/journal.pone.0037135
Subjects
free text keywords: Genetics, Evolutionary Biology, Biological Sciences, digest, inexpensive, snp, genotyping, non-model
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Dataset . 2017
Provider: figshare
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