research data . Dataset . 2016

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Li, Minyan; Huang, Rui; Jiang, Xue; Chen, Yuxi; Zhang, Zhen; Zhang, Xiya; Liang, Puping; Zhan, Shaoquan; Cao, Shanbo; Songyang, Zhou; ...
  • Published: 01 Jan 2016
  • Publisher: Figshare
Abstract
<div><p>Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It is hard to uncover the real function of a testis specific gene <i>in vitro</i> since the <i>in vitro</i> model is not yet mature. With the development of the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9) system, we can now rapidly generate knockout mouse models of testis specific genes to study the process of spermatogenesis <i>in vivo</i>. SYCP3-like X-linked 2 (SLX2) is a germ cell specific component, which contains a Cor1 domain and belongs to the XLR (X-linked, lymphocyte regulated) family. Previous studies suggeste...
Subjects
free text keywords: Biological Sciences, Vivo Mammalian spermatogenesis, Slx 2 knockout, testi, Slx 2, xlr, Cor 1 domain, Slx 2 knockout mice, Clustered Regularly Interspaced, function, XY body formation, Slx 2 gene, vivo, mouse spermatogenesis, SYCP, crispr, knockout mouse models
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Dataset . 2016
Provider: figshare
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